Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish zebrafish. [DOI] 10.3390/ijms231710130 PMC 바로가기
Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors다양한 세포 유형에서 SARS-CoV-2 감염에 대한 비교 연구: 잠재적 수용체의 역할에 대한 생물물리학적 전산적 접근Article Published on 2022-03-012022-09-12 Journal: Computers in biology and medicine [Category] MERS, SARS, 진단, [키워드] A549 ACE2 addition AGTR2 angiotensin-converting enzyme 2 approach CD147 Cell cell line cell lines Cell susceptibility cellular Comparative conditions dependent on docking early infection expected experiment expression expression level expression levels greater Heat shock HEK293 HepG2 Host host protein HSPA5 Infection Interaction kinetic less Lungs macromolecular Macromolecular crowding membrane NRP1 NTERA-2 parameter predict predicted promote protease Protein Quantitative receptor receptors Research respiratory tract SARS CoV-2 SARS-COV-2 infection serine 2 stimulate susceptibility TMPRSS2 transcriptomic data transmembrane viral dynamics viral growth viral spike Viral spike. virus [DOI] 10.1016/j.compbiomed.2022.105245 PMC 바로가기 [Article Type] Article
Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19혈전증 관련 순환 miR-16-5p는 COVID-19로 입원한 환자의 질병 중증도와 관련이 있습니다Article Published on 2022-01-012022-09-11 Journal: RNA Biology [Category] 바이오마커, [키워드] 95% CI ACE2 ACE2 receptor activated acute respiratory syndrome acute respiratory syndrome coronavirus Admission amyloid amyloid beta Analysis angiotensin Angiotensin-converting enzyme app approach Area baseline baseline expression Beta bioinformatic analysis bioinformatics Bioinformatics analysis Biomarker Blood Blood cells body mass CALM1 calmodulin can be used changes in chronic obstructive circulating class Co-expression analysis Coagulation composite endpoint condition Control Coronary artery coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 complications COVID-19 patient cyclin dataset death diabete diabetes Diabetes Mellitus diagnostic disease disease severity EGFR ELAVL1 enzyme expression expression level expression levels expressions family Fibronectin Filamin FLNA FN1 Follow-up Gene Expression Genes growth factor healthy controls healthy volunteer heat Heat shock heat shock protein hospital hospitalised hospitalized COVID-19 patient HSP90AA1 Human hypercoagulable in silico in silico prediction independent predictor independent predictors individual inflammatory reaction intensive care interquartile let-7b-5p Like member microRNA MicroRNAs microRNAs. miR-155 miR-16-5p miRNA miRNAs Multivariate analysis Myocardial nuclear pathway Pathways Patient patients hospitalized patients with COVID-19 performed peripheral Peripheral blood phosphatase play role polymerase chain positive Predictive prognostic biomarker Prognostic biomarkers Protein PTEN qRT-PCR Quantitative receptor Regulatory RNA SARS-CoV-2 selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severity of infection silico prediction silico predictions Stratification tensin the healthy THROMBOPLASTIN thrombosis thrombotic Toll-like receptor TP53 UBC ubiquitin utility White blood cells [DOI] 10.1080/15476286.2022.2100629 PMC 바로가기 [Article Type] Article
Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19혈장 gp96은 심한 covid-19에 대한 새로운 예측 바이오 마커입니다.Research Article Published on 2021-11-242022-08-31 Journal: Microbiology Spectrum [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory illness analyzed coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID‐19 Critical DAMPs danger-associated molecular pattern danger-associated molecular patterns disease disease severity effective elevated evaluate Fever Heat shock heat shock protein heat shock proteins hospital Hospitalization Hsps IL-6 IMPROVE indicated Injury interleukin interleukin-6 less Mild monocyte Monocytes non-COVID-19 patient Non-COVID-19 patients novel outcome oxidative stress patients patients with COVID-19 plasma plasma concentration plasma concentrations plasma gp96 poor prognosis positively correlated predicted Predictive predictive biomarker prognostic biomarker Protein released respiratory Respiratory illness respiratory impairment respiratory symptoms severe coronavirus disease severe COVID-19 Severe patient severe patients significantly significantly higher Viral viral infection with COVID-19 [DOI] 10.1128/Spectrum.00597-21 PMC 바로가기 [Article Type] Research Article
SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid dropletsResearch Article Published on 2021-11-222022-10-31 Journal: Febs Letters [Category] COVID-19, [키워드] A549 A549 cell approach association biological processe blocked cancer cell Cancer cells cells droplet epithelial exhibited G3BP1 G3BP2 Heat shock human lung interact Interaction investigated liquid–liquid phase separation mitoxantrone N protein NCAP nucleocapsid nucleocapsid protein oxidative oxidative stress PKR Protein provide RNA RNA degradation RNase SARS‐CoV‐2 SARS‐CoV‐2 SILAC Stress stress granule stress granules translocated Treatment undergo USP10 viral factory viral infection YTHDF3 [DOI] 10.1002/1873-3468.14229 PMC 바로가기 [Article Type] Research Article
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19Article Published on 2021-11-152022-10-28 Journal: Biology [Category] COVID-19, [키워드] “COVID-19 “cytokine storm” 20S proteasome acute respiratory syndrome addition analyzed ARDS association AUC Biomarker blood draw cause clinical clinical picture collected Coronavirus-2 Course COVID-19 COVID-19 disease COVID-19 patients COVID-2019 Critical critical appraisal demonstrated described disease disintegration Disseminated intravascular coagulation elevated endpoints evidenced Heat shock help high-risk patient higher risk hospital Hospital admission HSP27 Human hyperinflammation identify immune immune system immunological in-hospital mortality independent indicated Infection Inflammatory Inflammatory cytokine Interpretation invasive ventilation investigated mechanism Mortality notable outbreak oxygen support pandemic pathophysiology Patient patients with COVID-19 plasma Prognostic factor Prognostic factors proteasome Protein Relevance remained Research risk SARS-CoV-2 Sepsis septic patient serological data serum serum sample simple sST2 ST2 subsequent therapeutic interventions undergo Ventilation with COVID-19 [DOI] 10.3390/biology10111186 PMC 바로가기 [Article Type] Article
Heat shock protein 70 could enhance porcine epidemic diarrhoea virus replication by interacting with membrane proteinsResearch Article Published on 2021-10-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] assays Cell cells cellular complex diarrhoea downregulated early stage ENhance Epidemic expression Heat shock heat shock protein heat shock protein 7 Hsp70 immunofluorescence immunoprecipitation Infection investigated M protein membrane membrane protein MOST overexpression PEDV Porcine epidemic diarrhoea virus Protein protein expression reduction in Replication resulting significantly structural protein virions virus virus replication [DOI] 10.1186/s13567-021-01006-9 PMC 바로가기 [Article Type] Research Article
Analytical and clinical evaluation of a heat shock SARS-CoV-2 detection method without RNA extraction for N and E genes RT-qPCRN 및 E 유전자 RT-qPCR에 대한 RNA 추출 없이 열충격 SARS-CoV-2 검출 방법의 분석 및 임상 평가Article Published on 2021-08-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] analytical sensitivity analyzed caused CDC clinical evaluation COVID-19 COVID-19 pandemic Diagnosis E gene Ecuador evaluate heat Heat shock help Laboratory limit of detection Molecular diagnosis N gene Nasopharyngeal samples overcome positive positive sample protocol protocols public health RNA extraction RNA extraction free RNA extraction kits RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 positive patient SARS-CoV-2. sensitivity specimens supply shortage Viral RNA [DOI] 10.1016/j.ijid.2021.06.038 PMC 바로가기 [Article Type] Article
Autoantibodies to heat shock protein 60, 70, and 90 are not altered in the anti-SARS-CoV-2 IgG-seropositive humans without or with mild symptoms열 충격 단백질 60, 70 및 90에 대한 자가항체는 항SARS-CoV-2 IgG 혈청 양성인 사람에서 경증의 증상이 있거나 없는 변경되지 않습니다.Short Communication Published on 2021-06-022022-09-12 Journal: Cell stress & chaperones [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 anti-SARS-CoV-2 antibody autoantibodies autoantibody Autoimmunity cellular organelles chaperone circulating conserved COVID-19 cytoplasm dose elicit enzyme-linked immunosorbent evaluate evaluated Extracellular healthy healthy volunteer Heat shock heat shock protein Heat shock proteins, Hsps Human humoral immune response Hypothesis IgA IgG IgM Immunity immunogenic include member Mild symptom molecular mRNA vaccine naïve participant Proteases Protein released remained SARS-CoV-2 Serum level Severe acute respiratory syndrome corona virus 2, SARS-CoV-2 stress conditions viral spike protein virus Volunteer volunteers [DOI] 10.1007/s12192-021-01215-3 PMC 바로가기 [Article Type] Short Communication